The most popular and loved Anti hyperlipidemics world wide are the Statins. Mechanism of Action: They act by inhibiting HMG CoA Reductase enzyme. The results of Statin use over lipid profile may be listed as below- Decreased Liver Cholesterol levels. Decreased LDL. Decreased VLDL synthesis and Decreased Triglycerides. Increased HDL cholesterol to some extent. Increased LDL receptor expression. Since HMG CoA Reductase activity is at its peak at midnight, Statins are given at bed time. But Atorvastatin and Rosuvastatins have long half lives (t1/2), therefore they need not be timed at bed time specifically. Statins are most potent LDL lowering agents. They are the number 1 drug of choice in case of Metabolic Syndrome (along with Metformin). Longest acting Statin is Rosuvastatin (14 hrs half life). The Statins also have anti-inflammatory and anti-oxidant properties (especially Atorvastatin), thereby making them good drugs to prevent atherosclerosis and giving ...
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