Mnemonic: DUMBBELSS Diarrhea Urination Miosis Bradycardia Bronchoconstriction Excitation (Muscle, CNS)- Nicotinic effects Lacrimation Salivation Sweating Fata Dose: TEPP- 50mg- IM or 100mg- Orally OMPA 80mg IM or 175mg Orally Parathion 80mg IM or 175mg Orally HETP 60mg IM or 350mg Orally Malathion and Diazinon 1gm Orally Cause of Death: Paralysis of respiratory muscles, respiratory failure and intense bronchoconstriction. Management: For Muscaranic effects- Atropine is drug of choice (Tachycardia is not a contraindication for atropine administration) For Regeneration of AchE- Pralidoxime (2-PAM) Time dependent aging requires administration of PAM as soon as possible.
Science progresses by questioning the existing dogmas.