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The most popular and loved Anti hyperlipidemics world wide are the Statins. Mechanism of Action:  They act by inhibiting HMG CoA Reductase enzyme. The results of Statin use over lipid profile may be listed as below- Decreased Liver Cholesterol levels. Decreased LDL. Decreased VLDL synthesis and Decreased Triglycerides. Increased HDL cholesterol to some extent. Increased LDL receptor expression. Since HMG CoA Reductase activity is at its peak at midnight, Statins are given at bed time. But Atorvastatin and Rosuvastatins have long half lives (t1/2), therefore they need not be timed at bed time specifically. Statins are most potent LDL lowering agents.  They are the number 1 drug of choice in case of Metabolic Syndrome (along with Metformin). Longest acting Statin is Rosuvastatin (14 hrs half life). The Statins also have anti-inflammatory and anti-oxidant properties (especially Atorvastatin), thereby making them good drugs to prevent atherosclerosis and giving ...

A 20 year female with 36 weeks pregnancy presents for the first evaluation.She is diagnosed Chlamydia trachomatis infection of cervix.Upon delivery,what complaint is the infant most at risk for ? a.Jaundice b.Hydrocephalus. c.Hutchinson triad d.Conjunctivitis. E.Sensoryneural deafness. Ans : D Chlamydia can also be associated with pnuemonia and Otitis media. Hydrocephalus can be associated with toxoplasmosis. Hutchinson triad - (i)Hutchinson teeth (blunted upper incisors) (ii)Interstetial keratitis (iii)Eighth nerve deafness. This triad is seen in congenital syphilis. Sensorineural deafness is associated with Congenital rubella exposure. Treatment - Oral Erythromycin.