Acetylcholinesterase Inhibitor Poisoning- Mnemonic

Mnemonic: DUMBBELSS
Diarrhea
Urination
Miosis
Bradycardia
Bronchoconstriction
Excitation (Muscle, CNS)- Nicotinic effects
Lacrimation
Salivation
Sweating

Fata Dose:
TEPP- 50mg- IM or 100mg- Orally
OMPA 80mg IM or 175mg Orally
Parathion 80mg IM or 175mg Orally
HETP 60mg IM or 350mg Orally
Malathion and Diazinon 1gm Orally

Cause of Death:
Paralysis of respiratory muscles, respiratory failure and intense bronchoconstriction.

Management:
For Muscaranic effects- Atropine is drug of choice (Tachycardia is not a contraindication for atropine administration)
For Regeneration of AchE- Pralidoxime (2-PAM)
Time dependent aging requires administration of PAM as soon as possible.

Comments

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