Skip to main content

Story of Vitamin B17/Amygdalin/Laetrile/ and Cancer

Image
By Dr. Ahmed

Amygdalin is a compound found in seeds of all fruits except those of citrus fruits. It is found in high amounts in Apricot kernels and Almonds.

 Anti-tumor properties of Amygdalin have been discussed and argued over and over through out the cancer research circles. A quick google search of 'Amygdalin' will tell you that it is a 'quack medicine', that it has no action on cancer cells and that it is dangerously poisonous substance. Laetrile is the name of semi-synthetic (drug- tablet and injection) form of amygdalin available in the market.


 Let me present the readers with PubMed articles - published data in prestigious peer reviewed journals, regarding the anti-tumor properties of Amygdalin. Links will be provided with each statement.
  • Amygdalin has anti-tumor tumor properties. It has antitussive and antiasthamatic effects. It has apoptotic effect on Renal Fibroblasts- helpful in chronic kidney disease. It stimulates the immune system and acts as an analgesic. Toxic dose in human is around 4 grams per day for 15 days. Toxicity can be avoided if dose is reduced to 1 gram per day. Source: PubMed-25207888 and Full Article at CancerJournal. 
  • Amygdalin influences bladder cancer cell migration, adhesion and invasion by modulation beta1 and beta4 integrins. Source: PubMed-25333694. 
  • Amygdalin mediated Non-small cell lung cancer cell invasion in vitro: "In summary, this study showed that amygdalin inhibited the in vitro proliferation, invasion and migration of NSCLC. The mechanisms may be related to the more extensive regulation of gene expression by regulating integrin and E-cadherin expression, and the downstream key signaling pathways such as Akt-mTOR." Source: PubMed-PMC4503109. 
  • Chinese medicine amygdalin and β-glucosidase combined with antibody enzymatic prodrug system as a feasible antitumor therapy: "The Chinese medicine amarogentin (amygdalin) and β-glucosidase will become an important treatment for various tumors when an appropriate monoclonal antibody is developed." Source: PubMed-26272547.
  • Amygdalin blocks bladder cancer cell growth in vitro by diminishing cyclin A and cdk2. Source: PubMed-25136960.
  • Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells. Source: PubMed-16880611.
  • Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells. Source: PubMed-23137229. 
  • Amygdalin inhibits renal fibrosis in chronic kidney disease. Source: PubMed-23525378. 
It is quite clear that there is overwhelming data showing some kind of antitumor action of amygdalin.  I have to mention here that Amygdalin is not approved by US FDA as a cancer drug/treatment. More research and control trials are needed to devise a protocol for amygdalin to be used as an anticancer drug. At the same time, outrightly accusing amygdalin as a 'quack medicine' is unfair.

Update: This article was used as a reference by authors at 'Journal of Molecular Pharmaceuticals and Regulatory Affairs.' Click here. 
Labels:

Comments

Post a Comment

Popular posts from this blog

FDA is infamous for 'approving' deadly drugs: Pfizer's Covid19 vaccine is one of them.

By Dr. Ahmed
FDA approved does not mean safe. The FDA in recent years has been approving some deadly medicines that kill people, only to later 'recall' them from the market. By the time the pharmaceutical company (makers of the deadly drug) make huge profits and FDA people get their cut through legalized quid pro quo. Making money out of people's health is nothing new for those sitting in high positions of the 'health industry'. Infact it has reached a sadistic proportions where these people enjoy it. Because now the Big Pharma is involved in eugenics and depopulation agenda.  Still in Clinical Trails but 'Approved'. Forget about the 'rare' drugs or drugs used in rare diseases, a common, over the counter heart burn medicine such as Ranitidine (Rantac/Zantac) was pulled off the market by the FDA because it had a carcinogenic substance called NDMA in it. It has been known to cause heart attacks, liver failure, triggering porphyria attacks and pneumonia . Imagin...
Post a Comment
Read more

Acne

By Dr. Ahmed
Acne Vulgaris : Acne vulgaris is a self limiting disorder of teenagers and young adults.But 10-20% of adults may continue to experience this disorder. In adolescence, there is increased secretion of sebum from sebaceous glands. The glands get blocked with the retained sebum and kerotinous debris. Small cysts called Comedons are formed due to blockage of hair follicles. Proprionobacterium acnes is the cyst and caused production of fatty acids within the cysts. Thus causing infection of the cyst and bursting of the cyst wall. The extrusion of oily, keratinous debris triggers a foreign body reaction develops. Comedones : These are of two types- Closed comedones = White heads. Opened comedones = Black heads. The closed comedones are mostly associated with inflammatory lesions like papules , cysts and nodules. These are seen as small white heads with the naked eye or sometimes are not visible to the naked eye. The Open comedones are seen as Black heads. These are more st...
2 comments
Read more

Pathology- Cardiac Tumors

By Dr. Ahmed
Cardiac Myxoma: It is derived from the Mesenchyme and usually arise within the left atrium near the fossa ovalis. It restrict the blood flow to left ventricle. Shows constitutional signs of fever, weight loss and anemia. Microscopic picture- Stellate shaped cells in the myxoid background. Complications- Embolism (mostly in the brain), Ball valve obstruction of valves. Cardiac Rhabdomyomas: Benign tumour arising from myocardium.. Associated with Tuberous sclerosis . Metastatic Disease: Most commonly from Lungs. This is more common than primary cardiac tumors.
Post a Comment
Read more