Reversible Injury:
1. Decreased synthesis of ATP by oxidative phosphorylation.
2. Decrease function of Na-K ATPase pump-
- Influx of sodium and efflux of potassium
- Swelling of cell and endoplasmic reticulum.
- Depletion of cytoplasmic glycogen,
- Increased lactic acid production
- Decreased PH of the cell
- Massive influx of calcium into the cell- Large flocculant densities in the matrix.
- Efflux of intra cellular enzymes into circulation.
- Mitochondrial swelling
- Large densities in mitochondrial matrix
- Irreparable damage of oxidative phosphorylation
- Inability to produce ATP
- Release of lysosomal digestive enzymes into cytosol
- Activation of acid hydrolases followed by autolysis
- Pyknosis- degeneration and condensation of nuclear chromatin
- Karyorrhexis- Nuclear fragmentation
- Karyolysis- dissolution of nucleus.
Comments