Sequential changes in MI

Gross sequence of Changes in MI

Time	Predominant finding
0 to 18 hours	No gross changes
18 to 24 hours	Vague pallor and softening
1 to 7 days	Yellow scar
7 to 28 days	Central scar formation with red border
Months	Thick white Firm scar formation

Microscopic changes in MI

Survival Time	Predominant Finding
1-4 hours	Wavy myocyte fibers, contraction bands
4-24 hours	Coagulative necrosis
1 to 3 days	Neutrophil infiltration
3 to 7 days	Macrophage infiltration
7 to 28 days	Granulation tissue
Months	Fibrotic scar

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