Sequential changes in MI

Gross sequence of Changes in MI

Time	Predominant finding
0 to 18 hours	No gross changes
18 to 24 hours	Vague pallor and softening
1 to 7 days	Yellow scar
7 to 28 days	Central scar formation with red border
Months	Thick white Firm scar formation

Microscopic changes in MI

Survival Time	Predominant Finding
1-4 hours	Wavy myocyte fibers, contraction bands
4-24 hours	Coagulative necrosis
1 to 3 days	Neutrophil infiltration
3 to 7 days	Macrophage infiltration
7 to 28 days	Granulation tissue
Months	Fibrotic scar

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FDA is infamous for 'approving' deadly drugs: Pfizer's Covid19 vaccine is one of them.

FDA approved does not mean safe. The FDA in recent years has been approving some deadly medicines that kill people, only to later 'recall' them from the market. By the time the pharmaceutical company (makers of the deadly drug) make huge profits and FDA people get their cut through legalized quid pro quo. Making money out of people's health is nothing new for those sitting in high positions of the 'health industry'. Infact it has reached a sadistic proportions where these people enjoy it. Because now the Big Pharma is involved in eugenics and depopulation agenda. Still in Clinical Trails but 'Approved'. Forget about the 'rare' drugs or drugs used in rare diseases, a common, over the counter heart burn medicine such as Ranitidine (Rantac/Zantac) was pulled off the market by the FDA because it had a carcinogenic substance called NDMA in it. It has been known to cause heart attacks, liver failure, triggering porphyria attacks and pneumonia . Imagin...

Acne

Acne Vulgaris : Acne vulgaris is a self limiting disorder of teenagers and young adults.But 10-20% of adults may continue to experience this disorder. In adolescence, there is increased secretion of sebum from sebaceous glands. The glands get blocked with the retained sebum and kerotinous debris. Small cysts called Comedons are formed due to blockage of hair follicles. Proprionobacterium acnes is the cyst and caused production of fatty acids within the cysts. Thus causing infection of the cyst and bursting of the cyst wall. The extrusion of oily, keratinous debris triggers a foreign body reaction develops. Comedones : These are of two types- Closed comedones = White heads. Opened comedones = Black heads. The closed comedones are mostly associated with inflammatory lesions like papules , cysts and nodules. These are seen as small white heads with the naked eye or sometimes are not visible to the naked eye. The Open comedones are seen as Black heads. These are more st...

Pathology- Cardiac Tumors

Cardiac Myxoma: It is derived from the Mesenchyme and usually arise within the left atrium near the fossa ovalis. It restrict the blood flow to left ventricle. Shows constitutional signs of fever, weight loss and anemia. Microscopic picture- Stellate shaped cells in the myxoid background. Complications- Embolism (mostly in the brain), Ball valve obstruction of valves. Cardiac Rhabdomyomas: Benign tumour arising from myocardium.. Associated with Tuberous sclerosis . Metastatic Disease: Most commonly from Lungs. This is more common than primary cardiac tumors.

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