Wagers granulomatosis- Pathology, CVS

Wagner's granulomatosis is a kind of autoimmune disorder affecting the arteries. Medium sized and small arteries are involved. This is a kind of necrotizing vasculitis with granulomas. Its more common in males than in females. Mostly occurs at the age group of 40-60. Classically involves Nose, Sinuses, Lungs and kidneys.

Clinical Features:

Bilateral pneumonitis with nodular and cavity pulmonary infiltrates.
Chronic sinusitis.
Nasopharyngeal ulcerations.
Focal necrotizing glomerulosclerosis and Crescentic glomerulosclerosis are the two important forms of Renal pathology observed.

Microscopic picture:
Fibrinoid necrosis, Neutrophils and granulomas.

Lab findings:
Cytoplasmic antineutrophil cytoplasmic auto antibodies(C-ANCA)
Auto antibody against proteinase 3

Diagnosis is confirmed by biopsy

Treatment is by giving immunosuppresive drugs like Cyclophosphamide.

Comments

Mr. Drosten's strange relationship to freedom of expression

Christian Drosten This is Christian Drosten , who is responsible for the Covid PCR protocol that bypassed the peer review process. There most likely wouldn't have been any pandemic if he hadn't committed scientific fraud. The irony is that he now appears to be advocating for the restriction of scientific freedom in favor of health policy, a notion that's completely unconstitutional. During a discussion at the "World Health Summit" in October, Drosten emphasized the rise in misinformation online, especially during the COVID-19 'pandemic', and urged media and fellow scientists to correct false information. He suggested that scientific institutions should select and spotlight individuals who are 'true experts' in their fields to combat misinformation. The concern arises as to who gets to decide who these "true experts" are. Is Drosten volunteering himself for this role? His past statements might suggest so. Drosten, in a previous interview...

Pemphigus Vulgaris

Pemphigus vulgaris is a blistering autoimmune skin lesion mostly seen in elderly patients.The disorder is characterised by a process called Acanthoysis (loss of cohesion between epidermal cells).Lesions are mostly flaccid blisters over the skin.These blisters burst out and the surounding skin gets denuded.In severe cases, substantial portions of the body get denuded.Manual pressue over these blisters can cause separation of epidermis.This is known as Nikolsky's sign. This finding is a characteristic feature of Pemphigus vulgaris but not the specific feature. Nikolsky's sign is also seen in Stevens Johnson Syndrome, Toxic epidermal necrolysis and few other skin conditions. Clinical Features: Sometimes the disorder starts with pruritis(itching).Lesions in Pemphigus vulgaris are usually seen over the oral mucosa, scalp, axilla, trunk, face, neck .Blisters are usually seen in the mouth first and then on other mucosa (pharyngeal, laryngeal, oesophageal, conjunctival, vulval or r...

Story of Vitamin B17/Amygdalin/Laetrile/ and Cancer

Amygdalin is a compound found in seeds of all fruits except those of citrus fruits. It is found in high amounts in Apricot kernels and Almonds. Anti-tumor properties of Amygdalin have been discussed and argued over and over through out the cancer research circles. A quick google search of 'Amygdalin' will tell you that it is a 'quack medicine', that it has no action on cancer cells and that it is dangerously poisonous substance. Laetrile is the name of semi-synthetic (drug- tablet and injection) form of amygdalin available in the market. Let me present the readers with PubMed articles - published data in prestigious peer reviewed journals, regarding the anti-tumor properties of Amygdalin. Links will be provided with each statement. Amygdalin has anti-tumor tumor properties. It has antitussive and antiasthamatic effects. It has apoptotic effect on Renal Fibroblasts- helpful in chronic kidney disease. It stimulates the immune system and acts as an analg...

+ Health and Sciences +

Search This Blog