Wagers granulomatosis- Pathology, CVS

Wagner's granulomatosis is a kind of autoimmune disorder affecting the arteries. Medium sized and small arteries are involved. This is a kind of necrotizing vasculitis with granulomas. Its more common in males than in females. Mostly occurs at the age group of 40-60. Classically involves Nose, Sinuses, Lungs and kidneys.

Clinical Features:

Bilateral pneumonitis with nodular and cavity pulmonary infiltrates.
Chronic sinusitis.
Nasopharyngeal ulcerations.
Focal necrotizing glomerulosclerosis and Crescentic glomerulosclerosis are the two important forms of Renal pathology observed.

Microscopic picture:
Fibrinoid necrosis, Neutrophils and granulomas.

Lab findings:
Cytoplasmic antineutrophil cytoplasmic auto antibodies(C-ANCA)
Auto antibody against proteinase 3

Diagnosis is confirmed by biopsy

Treatment is by giving immunosuppresive drugs like Cyclophosphamide.

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